2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105052
    SC 34301
    SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice.
    SC 34301
  • HY-159704
    9-Keto-latanoprost
    		Control
    9-keto latanoprost is a derivative of the F-prostaglandin (FP) receptor agonist Latanoprost (HY-B0577).
    9-Keto-latanoprost
  • HY-124192
    Amogastrin
    		Inhibitor
    Amogastrin is a tetrapeptide that stimulates gastric extraction of 99mTc pertechnetate. Amogastrin can be used for the research of gastric mucosal disease imaging. Amogastrin stimulates the production of prostate hormones.
    Amogastrin
  • HY-108308
    Ibuprofen guaiacol ester
    		Inhibitor 98.49%
    Ibuprofen guaiacol ester (AF 2259; Metoxibutropate) is a potent and orally active prostaglandin synthesis inhibitor. Ibuprofen guaiacol ester has the potential for the research of edema and fever.
    Ibuprofen guaiacol ester
  • HY-131696
    11-deoxy Prostaglandin F1α
    		Control
    11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor.
    11-deoxy Prostaglandin F1α
  • HY-17350
    Anitrazafen
    		Inhibitor
    Anitrazafen is a topically effective antiinflammatory agent.
    Anitrazafen
  • HY-137585
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
    		Control
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid (HY-125774).
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
  • HY-105315
    AFP-07
    		Agonist
    AFP-07 is a derivative of 7, 7-difluoroprostacyclic and is a highly potent and selective prostacyclin receptor IP receptor agonist with a Ki value of 0.561 nM.
    AFP-07
  • HY-120955
    (+)-5-trans Cloprostenol
    		Control
    Cloprostol, a synthetic derivative of prostaglandin F2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol.
    (+)-5-trans Cloprostenol
  • HY-118772
    17-Phenyl trinor prostaglandin A2
    17-Phenyl trinor prostaglandin A2 is a synthetic prostaglandin analog.
    17-Phenyl trinor prostaglandin A2
  • HY-125737
    15-deoxy-Δ12,14-Prostaglandin J2 Glutathione
    		Control
    15-deoxy-Δ12,14-Prostaglandin J2 glutathione (15-deoxy-Δ12,14-PGJ2 glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione. The biological properties of this compound have not been characterized.
    15-deoxy-Δ12,14-Prostaglandin J2 Glutathione
  • HY-108415R
    Cloprostenol sodium salt (Standard)
    		Agonist
    Cloprostenol sodium salt (Standard) is the analytical standard of Cloprostenol sodium salt. This product is intended for research and analytical applications. Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.
    Cloprostenol sodium salt (Standard)
  • HY-130395
    15-Keto latanoprost
    		Agonist
    15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent.
    15-Keto latanoprost
  • HY-B0191AS
    5,6-trans-Bimatoprost-d5
    5,6-trans-Bimatoprost-d5 (5,6-trans-AGN 192024-d5) is the deuterium labeled 5,6-trans-Bimatoprost (HY-B0191A). 5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
    5,6-trans-Bimatoprost-d<sub>5</sub>
  • HY-113756
    trans-​Latanoprost acid
    		Control
    trans-Latanoprost acid is an isomer of Latanoprost acid. trans-Latanoprost acid may have the activity of reducing intraocular pressure. trans-Latanoprost acid is mainly prepared as an analytical standard for impurity detection and quantification.
    trans-​Latanoprost acid
  • HY-129953F
    Prostaglandin F2α-biotin
    Prostaglandin F2α-biotin (PGF2α-biotin) is a biotinylated form of Prostaglandin F2α (HY-12956). Prostaglandin F2α-biotin can be used in the study of the mechanism of action of prostaglandins. In addition, Prostaglandin F2α-biotin can be detected in the ethanolic extract of Hawm Gra Dang Ngah rice.
    Prostaglandin F2α-biotin
  • HY-14839A
    Evatanepag sodium
    		Agonist
    Evatanepag sodium is a non-prostanoid, potent and selective EP2 receptor agonist. Evatanepag sodium can induce local bone formation in vivo. Evatanepag sodium can be used in the research of fractures, bone defects, asthma.
    Evatanepag sodium
  • HY-137288
    17-Phenyl-18,19,20-trinor-PGD2
    		Control
    17-Phenyl-18,19,20-trinor-PGD2 (17-Phenyl-PGD2) is an analogue of prostaglandin D2 (PGD2; HY-101988). 17-Phenyl-18,19,20-trinor-PGD2 is a potent inhibitor of platelet aggregation caused by aenosine diphosphate (ADP), with the IC50 of 8.4 μM (PGD2 IC50 = 18.6 nM). 17-Phenyl-18,19,20-trinor-PGD2 is a weak agonist of cyclic AMP accumulation.
    17-Phenyl-18,19,20-trinor-PGD2
  • HY-150685
    Topo I/COX-2-IN-1
    		Inhibitor
    Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity.
    Topo I/COX-2-IN-1
  • HY-137133
    Prostaglandin E1 alcohol
    		Control
    Prostaglandin E1 alcohol (compound 89) is a prostaglandin analog.
    Prostaglandin E1 alcohol
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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