2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-130304
    8-Isoprostaglandin E2
    		Activator 99.0%
    8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A2 (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway.
    8-Isoprostaglandin E2
  • HY-B0813R
    Treprostinil diethanolamine (Standard)
    		Agonist
    Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
    Treprostinil diethanolamine (Standard)
  • HY-105218
    Ifetroban
    		Antagonist 99.65%
    Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research.
    Ifetroban
  • HY-142658
    BAY-6672
    		Antagonist
    BAY-6672, a chemical probe, is a potent and selective human Prostaglandin F (FP) receptor antagonist with an IC50 value of 11 nM.
    BAY-6672
  • HY-50175A
    Laropiprant sodium
    		Antagonist
    Laropiprant sodium is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
    Laropiprant sodium
  • HY-112604
    MK-8318
    		Antagonist
    MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
    MK-8318
  • HY-163376
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α.
    17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide
  • HY-105052
    SC 34301
    SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice.
    SC 34301
  • HY-159704
    9-Keto-latanoprost
    		Control
    9-keto latanoprost is a derivative of the F-prostaglandin (FP) receptor agonist Latanoprost (HY-B0577).
    9-Keto-latanoprost
  • HY-124192
    Amogastrin
    		Inhibitor
    Amogastrin is a tetrapeptide that stimulates gastric extraction of 99mTc pertechnetate. Amogastrin can be used for the research of gastric mucosal disease imaging. Amogastrin stimulates the production of prostate hormones.
    Amogastrin
  • HY-108308
    Ibuprofen guaiacol ester
    		Inhibitor 98.49%
    Ibuprofen guaiacol ester (AF 2259; Metoxibutropate) is a potent and orally active prostaglandin synthesis inhibitor. Ibuprofen guaiacol ester has the potential for the research of edema and fever.
    Ibuprofen guaiacol ester
  • HY-131696
    11-deoxy Prostaglandin F1α
    		Control
    11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor.
    11-deoxy Prostaglandin F1α
  • HY-17350
    Anitrazafen
    		Inhibitor
    Anitrazafen is a topically effective antiinflammatory agent.
    Anitrazafen
  • HY-137585
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
    		Control
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid (HY-125774).
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
  • HY-105315
    AFP-07
    		Agonist
    AFP-07 is a derivative of 7, 7-difluoroprostacyclic and is a highly potent and selective prostacyclin receptor IP receptor agonist with a Ki value of 0.561 nM.
    AFP-07
  • HY-120955
    (+)-5-trans Cloprostenol
    		Control
    Cloprostol, a synthetic derivative of prostaglandin F2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol.
    (+)-5-trans Cloprostenol
  • HY-124065
    ARRY-502
    		Antagonist
    ARRY-502 is an orally active, potent and selective CRTh2 antagonist. ARRY-502 blocks PGD2-mediated Th2 inflammation (e.g., eosinophil activation, airway hyperresponsiveness). ARRY-502 is promising for research of Th2-related asthma.
    ARRY-502
  • HY-118772
    17-Phenyl trinor prostaglandin A2
    17-Phenyl trinor prostaglandin A2 is a synthetic prostaglandin analog.
    17-Phenyl trinor prostaglandin A2
  • HY-125737
    15-deoxy-Δ12,14-Prostaglandin J2 Glutathione
    		Control
    15-deoxy-Δ12,14-Prostaglandin J2 glutathione (15-deoxy-Δ12,14-PGJ2 glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione. The biological properties of this compound have not been characterized.
    15-deoxy-Δ12,14-Prostaglandin J2 Glutathione
  • HY-W746847
    Epibetulinic acid-d3
    Epibetulinic acid-d3 is the deuterium labeled Epibetulinic acid (HY-N0223). Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity.
    Epibetulinic acid-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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